Wild-type (senile) amyloidosis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide. The actual incidence of wild-type (senile) amyloidosis in particular is unknown. The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries. Patients with wild-type (senile) amyloidosis are almost always elderly (65 years of age or older). There is no racial predilection to wild-type (senile) amyloidosis. Men are traditionally more commonly affected by wild-type (senile) amyloidosis than women.

Epidemiology and Demographics

Incidence

The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide.^[1]
The actual incidence of wild-type (senile) amyloidosis in particular is unknown.

Prevalence

The prevalence of wild-type (senile) amyloidosis has not been determined.
It is estimated that approximately 25% of the people beyond the age of 80 have cardiac TTR deposition.^[2]

Mortality rate

The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries.^[3]

Age

Patients with wild-type (senile) amyloidosis are almost always elderly (65 years of age or older).

Race

There is no racial predilection to wild-type (senile) amyloidosis.

Gender

Men are traditionally more commonly affected by wild-type (senile) amyloidosis than women.^[4]

References

↑ Khan MF, Falk RH (November 2001). "Amyloidosis". Postgrad Med J. 77 (913): 686–93. PMC 1742163. PMID 11677276.
↑ G. G. 3rd Cornwell, W. L. Murdoch, R. A. Kyle, P. Westermark & P. Pitkanen (1983). "Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation". The American journal of medicine. 75 (4): 618–623. doi:10.1016/0002-9343(83)90443-6. PMID 6624768. Unknown parameter |month= ignored (help)
↑ Pepys MB (2006). "Amyloidosis". Annu. Rev. Med. 57: 223–41. doi:10.1146/annurev.med.57.121304.131243. PMID 16409147.
↑ Belinda Ng, Lawreen H. Connors, Ravin Davidoff, Martha Skinner & Rodney H. Falk (2005). "Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis". Archives of internal medicine. 165 (12): 1425–1429. doi:10.1001/archinte.165.12.1425. PMID 15983293. Unknown parameter |month= ignored (help)

[pmid116772762-1] Khan MF, Falk RH (November 2001). "Amyloidosis". Postgrad Med J. 77 (913): 686–93. PMC 1742163. PMID 11677276.

[2] G. G. 3rd Cornwell, W. L. Murdoch, R. A. Kyle, P. Westermark & P. Pitkanen (1983). "Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation". The American journal of medicine. 75 (4): 618–623. doi:10.1016/0002-9343(83)90443-6. PMID 6624768. Unknown parameter |month= ignored (help)

[pmid16409147-3] Pepys MB (2006). "Amyloidosis". Annu. Rev. Med. 57: 223–41. doi:10.1146/annurev.med.57.121304.131243. PMID 16409147.

[4] Belinda Ng, Lawreen H. Connors, Ravin Davidoff, Martha Skinner & Rodney H. Falk (2005). "Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis". Archives of internal medicine. 165 (12): 1425–1429. doi:10.1001/archinte.165.12.1425. PMID 15983293. Unknown parameter |month= ignored (help)

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