Urticaria natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2]


Remission rate, complications and prognosis of urticaria is tightly related to patient characteristic (such as age and gender), subtype of urticaria and concurrent angioedema. 10% to 60% of cases go into remission within the first 5–10 years of disease diagnosis. Moreover treatments usually alleviate symptoms in most cases. Mean duration of urticaria presence is different among distinct sub-types. Urticaria patients are prone to some complications, such as superimposed bacterial infection, anaphylaxis and excoriation due to intense pruritus. Most patients improve over time, even stubborn cases. Prognosis and treatment response is better in patients younger than 19 years old, compared to older adults. Female gender, prolonged period of disease at the first visit, concurrent angioedema, subtypes such as physical urticaria and cholinergic urticaria and chronic use of non-steroidal anti-inflammatory drug are related to worse prognosis.

Natural History, Complications, and Prognosis

Natural History

Cold contact urticaria 4.2 years
Delayed‐pressure urticaria 6–9 years
Dermographic urticaria 6.5 years


Common complications of urticaria include:[2][3]



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  2. 2.0 2.1 2.2 Zuberbier T (2003). "Urticaria". Allergy. 58 (12): 1224–34. doi:10.1046/j.1398-9995.2003.00327.x. PMID 14616095.
  3. Valks R, Conde-Salazar L, Cuevas M (2004). "Allergic contact urticaria from natural rubber latex in healthcare and non-healthcare workers". Contact Dermatitis. 50 (4): 222–4. doi:10.1111/j.0105-1873.2004.00327.x. PMID 15186377.
  4. 4.0 4.1 Hiragun M, Hiragun T, Mihara S, Akita T, Tanaka J, Hide M (2013). "Prognosis of chronic spontaneous urticaria in 117 patients not controlled by a standard dose of antihistamine". Allergy. 68 (2): 229–35. doi:10.1111/all.12078. PMID 23205732.
  5. Gregoriou S, Rigopoulos D, Katsambas A, Katsarou A, Papaioannou D, Gkouvi A; et al. (2009). "Etiologic aspects and prognostic factors of patients with chronic urticaria: nonrandomized, prospective, descriptive study". J Cutan Med Surg. 13 (4): 198–203. doi:10.2310/7750.2008.08035. PMID 19706227.
  6. Puxeddu I, Petrelli F, Angelotti F, Croia C, Migliorini P (2019). "Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications". J Asthma Allergy. 12: 285–295. doi:10.2147/JAA.S184986. PMC 6759208 Check |pmc= value (help). PMID 31571935.
  7. Toubi E, Kessel A, Avshovich N, Bamberger E, Sabo E, Nusem D; et al. (2004). "Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients". Allergy. 59 (8): 869–73. doi:10.1111/j.1398-9995.2004.00473.x. PMID 15230821.
  8. Folci M, Heffler E, Canonica GW, Furlan R, Brunetta E (2018). "Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria". J Immunol Res. 2018: 5615109. doi:10.1155/2018/5615109. PMC 6280255. PMID 30584542.
  9. Poon E, Seed PT, Greaves MW, Kobza-Black A (1999). "The extent and nature of disability in different urticarial conditions". Br J Dermatol. 140 (4): 667–71. doi:10.1046/j.1365-2133.1999.02767.x. PMID 10233318.

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