Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. 
Systemic circulation is the portion of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. The term is contrasted with pulmonary circulation.
In the systematic circulation, arteries bring oxygenated blood to the tissues. As blood circulates through the body, oxygen diffuses from the blood into cells surrounding the capillaries, and carbon dioxide diffuses into the blood from the capillary cells. Veins bring deoxygenated blood back to the heart.
Template:Seealso Oxygenated blood enters the systemic circulation when leaving the left ventricle, through the aortic semi-lunar valve. The first part of the systemic circulation is the artery aorta, a massive and thick-walled artery. The aorta arches and gives off major arteries to the upper body before piercing the diaphragm in order to supply the lower parts of the body with its various branches.
Blood passes from arteries to capillaries, which are the thinnest and most numerous of the blood vessels. These capillaries help to join tissue with arterioles for transportation of nutrition to the cells, which absorb oxygen and nutrients in the blood. Peripheral tissues do not fully deoxygenate the blood, so venous blood does have oxygen, but in a lower concentration than in arterial blood. In addition, carbon dioxide and wastes are added.
The deoxygenated blood is then collected by venules, from where it flows first into veins, and then into the inferior and superior venae cavae, which return it to the right heart, completing the systemic cycle. The blood is then re-oxygenated through the pulmonary circulation before returning again to the systemic circulation.
The relatively de-oxygenated blood collects in the venous system which coalesces into two major veins: the superior vena cava (roughly speaking from areas above the heart) and the inferior vena cava (roughly speaking from areas below the heart). These two great vessels exit the systemic circulation by emptying into the right atrium of the heart. The coronary sinus empties the heart's veins themselves into the right atrium.
Because the systemic circulation is powered by the left ventricle (which is very muscular), one advantage of this form of circulation - as opposed to open circulation, or the gill system that fishes use to breathe - is that there is simultaneous high-pressure oxygenated blood delivered to all parts of the body.
Template:Arteries of head and neck Template:Arteries of upper limbs Template:Arteries of chest Template:Arteries of abdomen Template:Arteries of lower limbs