Motor protein

Jump to navigation Jump to search

WikiDoc Resources for Motor protein


Most recent articles on Motor protein

Most cited articles on Motor protein

Review articles on Motor protein

Articles on Motor protein in N Eng J Med, Lancet, BMJ


Powerpoint slides on Motor protein

Images of Motor protein

Photos of Motor protein

Podcasts & MP3s on Motor protein

Videos on Motor protein

Evidence Based Medicine

Cochrane Collaboration on Motor protein

Bandolier on Motor protein

TRIP on Motor protein

Clinical Trials

Ongoing Trials on Motor protein at Clinical

Trial results on Motor protein

Clinical Trials on Motor protein at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Motor protein

NICE Guidance on Motor protein


FDA on Motor protein

CDC on Motor protein


Books on Motor protein


Motor protein in the news

Be alerted to news on Motor protein

News trends on Motor protein


Blogs on Motor protein


Definitions of Motor protein

Patient Resources / Community

Patient resources on Motor protein

Discussion groups on Motor protein

Patient Handouts on Motor protein

Directions to Hospitals Treating Motor protein

Risk calculators and risk factors for Motor protein

Healthcare Provider Resources

Symptoms of Motor protein

Causes & Risk Factors for Motor protein

Diagnostic studies for Motor protein

Treatment of Motor protein

Continuing Medical Education (CME)

CME Programs on Motor protein


Motor protein en Espanol

Motor protein en Francais


Motor protein in the Marketplace

Patents on Motor protein

Experimental / Informatics

List of terms related to Motor protein


Motor proteins are a class of molecular motors that are able to move along the surface of a suitable substrate. They are powered by the hydrolysis of ATP and convert chemical energy into mechanical work.

Cellular functions

The most prominent example of a motor protein is the muscle protein myosin which "motors" the contraction of muscle fibers in animals. Motor proteins are the driving force behind most active transport of proteins and vesicles in the cytoplasm. Kinesins and dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. Dynein is found in flagella and is crucial to cell motility, for example in spermatozoa.

Diseases associated with motor protein defects

The importance of motor proteins in cells becomes evident when they fail to fulfill their function. For example, kinesin deficiencies have been identified as cause for Charcot-Marie-Tooth disease and some kidney diseases. Dynein deficiencies can lead to chronic infections of the respiratory tract as cilia fail to function without dynein. Defects in muscular myosin predictably cause myopathies, whereas defects in unconventional myosin are the cause for Usher syndrome and deafness.[1]


Most eukaryotic motor proteins consist of two distinct domains: A motor head domain with ATPase function and a tail domain that can either form fibers (muscle myosin) or attach to a cargo such as for example chromosomes during anaphase of mitosis (kinesin) or vesicles during endocytosis (dynein). The head domain of the proteins carries out the movement by binding to a specific site on the substrate and changing conformation depending on ATP hydrolysis. The tail end of the molecule normally binds adaptor proteins that allow for stable interactions with the cargo to be moved along the substrate.[2] These motor proteins typically form a complex of longer "heavy chains" with motor head domains and shorter "light chains" for stabilization.

Cytoskeletal motor proteins

Motor proteins utilizing the cytoskeleton for movement fall into two categories based on their substrates: Actin motors such as myosin move along microfilaments through interaction with actin. Microtubule motors such as dynein and kinesin move along microtubules through interaction with tubulin. There are two basic types of microtubule motors: plus-end motors and minus-end motors, depending on the direction in which they "walk" along the microtubule cables within the cell.

Actin motors


Myosins are actin motors and form myosin complexes consisting of two heavy chains with motor heads and two light chains. Derived from the Greek word for muscle, myosin is the protein responsible for generating muscle contraction. By non-processively walking along actin filaments, many molecules of myosin generate enough force to contract muscle tissue. Myosins are also vital in the process of cell division. They are also involved in cytoplasmic streaming, wherein movement along microfilament networks in the cell allows organelles and cytoplasm to stream in a particular direction. Eighteen different classes of myosins are known.[3]

Genomic representation of myosin motors: [4]

Microtubule motors


Kinesins are a group of related motor proteins that use a microtubule track along which to "walk." They are vital to movement of chromosomes during mitosis and are also responsible for shuttling mitochondria, Golgi bodies, and vesicles within eukaryotic cells. Kinesins typically contain two heavy chains with motor heads which move along microtubules via a pseudo-processive asymmetric walking motion, that can be towards the plus-end or the minus-end, depending on the type of kinesin. Fourteen distinct kinesin families are known, with some additional kinesin-like proteins that cannot be classified into these families.[5]

Genomic representation of kinesin motors: [4]


Dyneins are microtubule motors capable of a sliding movement. Dynein complexes are much larger and more complex than kinesin and myosin motors. Dynein facilitates the movement of cilia and flagella. Compared to 15 types of dynein for this function, only two cytoplasmic forms are known.[6]

Genomic representation of dynein motors: [4]

Plant-specific motors

In contrast to animals, fungi and non-vascular plants, the cells of flowering plants lack dynein motors. However, they contain a larger number of different kinesins. Many of these plant-specific kinesin groups are specialized for functions during plant cell mitosis.[7] Plant cells differ from animal cells in that they have a cell wall. During mitosis, the new cell wall is built by the formation of a cell plate starting in the center of the cell. This process is facilitated by a phragmoplast, a microtubule array unique to plant cell mitosis. The building of cell plate and ultimately the new cell wall requires kinesin-like motor proteins.[8]

Another motor protein essential for plant cell division is kinesin-like calmodulin-binding protein (KCBP), which is unique to plants and part kinesin and part myosin.[9]

Other molecular motors

Besides the motor proteins above, there are many more types of proteins capable of generating forces and torque in the cell. Among the processes regulated by force-generating proteins are:

Many of the molecular motors that regulate these processes are ubiquitous in both prokaryotic and eukaryotic cells, although some, like those involved with cytoskeletal elements or chromatin, are unique to eukaryotes.

See also


  1. Hirokawa N, Tekamura R (2003). "Biochemical and molecular characterization of diseases linked to motor proteins". Trends in Biochemical Sciences. 28: 558–565. PMID 14559185.
  2. Kamal A, Goldstein LSB (2002). "Principles of cargo attachment to cytoplasmic motor proteins". Current Opinion in Cell Biology. 14: 63–68. PMID 11792546.
  3. Thompson RF, Langford GM (2002). "Myosin superfamily evolutionary history". The Anatomical Record. 268: 276–289. PMID 12382324.
  4. 4.0 4.1 4.2 Vale RD (2003). "The molecular motor toolbox for intracellular transport". Cell. 112: 467–480. PMID 12600311.
  5. Miki H, Okada Y, Hirokawa N (2005). "Analysis of the kinesin superfamily: insights into structure and function". Trends in Cell Biology. 15: 467–476. PMID 16084724.
  6. Mallik R, Gross SP (2004). "Molecular motors: strategies to get along". Current Biology. 14: R971–R982. PMID 15556858.
  7. Vanstraelen M, Inze D, Geelen D (2006). "Mitosis-specific kinesins in Arabidopsis". Trends in Plant Science. 11: 167–175. PMID 16530461.
  8. Smith LG (2002). "Plant cytokinesis: motoring to the finish". Current Biology. 12: R202–R209. PMID 11909547.
  9. Abdel-Gany I, Day IS, Simmons PK, Reddy ASN (2005). "Origin and evolution of kinesin-like calmodulin-binding protein". Plant Physiology. 138: 1711–1722. PMID 15951483.
  10. Peterson C (1994). "The SMC family: novel motor proteins for chromosome condensation?". Cell. 79 (3): 389–92. PMID 7954805.

Template:WH Template:WS