Membranoproliferative glomerulonephritis causes

Jump to navigation Jump to search

Membranoproliferative glomerulonephritis Microchapters


Patient Information


Historical Perspective




Differentiating Membranoproliferative glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Membranoproliferative glomerulonephritis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis causes

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Membranoproliferative glomerulonephritis causes

CDC on Membranoproliferative glomerulonephritis causes

Membranoproliferative glomerulonephritis causes in the news

Blogs on Membranoproliferative glomerulonephritis causes

Directions to Hospitals Treating Membranoproliferative glomerulonephritis

Risk calculators and risk factors for Membranoproliferative glomerulonephritis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Nazia Fuad M.D.


The most common causes for membranoproliferative glomerulonephritis autoimmune diseases, mainly systemic lupus erythematosus (SLE), Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C2 deficiency), scleroderma, Celiac disease .Chronic infections also play major role such as viral infections like hepatitis B, hepatitis C, and cryoglobulinemia type II, bacterial infections such as endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy. Protozoal - malaria, schistosomiasis. Rare causes of MPGN include non-Hodgkin lymphoma, renal cell carcinoma, snake venom, splenorenal shunt surgery for portal hypertension , melanoma, alpha-1-antitrypsin deficiency, and cryoglobulinemic glomerulonephritis and Idiopathic MPGN .


Life- threatening Causes

There are no life-threatening causes of membranoproliferative glomerulonephritis. , however complications resulting from untreated membranoproliferative glomerulonephritis are common.

Common Causes

Common causes of MPGN may include:[1][2][3]

Less Common Causes

Less common causes of MPGN include

    • MPGN type I
    • MPGN type II or dense deposit disease.
    • MPGN type III
  • Paraprotein deposition diseases

Genetic Causes

  • MPGN is caused by a mutation in the complement factor H-related protein 5 (CFHR5) gene.

Causes by Organ System

Cardiovascular Endocarditis, infected ventriculoatrial (or jugular) shunt
Chemical/Poisoning Snake venom
Dental No underlying causes
Dermatologic Melanoma, Leprosy
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Celiac disease, hepatitis B and C, chronic liver disease

Splenorenal shunt surgery for portal hypertension

Alpha-1-antitrypsin deficiency

Genetic (CFHR5) gene mutation, Alpha-1-antitrypsin deficiency
Hematologic Sickle cell anemia, polycythemia and non-hodgkin lymphoma,




Hemolytic uremic syndrome

Iatrogenic No underlying causes
Infectious Disease Viral - hepatitis B, hepatitis C, and cryoglobulinemia type II

Bacterial - endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy

Protozoal - malaria, schistosomiasis

Other infections - mycoplasma, lyme Disease

Musculoskeletal/Orthopedic No underlying causes
Neurologic Leprosy
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Lymphoma, leukemia, carcinoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Mycoplasma pneumonia, alpha-1-antitrypsin deficiency
Renal/Electrolyte Rnal cell carcinoma

Hemolytic uremic syndrome

Radiation nephritis

Nephropathy associated with bone marrow transplantation

Transplant glomerulopathy

Rheumatology/Immunology/Allergy Systemic lupus erythematosus (SLE)

Sjögren syndrome

Rheumatoid arthritis


Celiac disease

Immunoglobulin light chain or heavy chain deposition diseases

Sexual No underlying causes
Trauma No underlying causes
Urologic Hemolytic uremic syndrome
Miscellaneous Chronic liver disease (cirrhosis and alpha1-antitrypsin deficiency)


  1. H. Terence Cook and Matthew C. Pickering (2014). "Histopathology of MPGN and C3 glomerulopathies". NATURE REVIEWS NEPHROLOGY.
  2. MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB (1978). "lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits". clinical immunology and immunopathology.
  3. Mårten Segelmark, Thomas Hellmark (2010). "Autoimmune kidney diseases". Elsevier.
  4. Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD (2004). "MPGN Secondary to Lyme Disease". American Journal of Kidney Diseases. 43.
  5. Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock (2012). "Idiopathic membranoproliferative glomerulonephritis: does it exist?". Nephrology Dialysis Transplantation ( NDT ).

Template:WH Template:WS