GUSTO bleeding criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

GUSTO Bleeding Criteria

Global Utilization Of Streptokinase And Tpa For Occluded Arteries definition for bleeding [1], [2]

1. Severe or Life-threatening:

2. Moderate:

  • Requiring blood transfusion but not resulting in hemodynamic compromise

3. Mild

  • Bleeding that does not meet above criteria


  1. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J; et al. (2011). "Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium". Circulation. 123 (23): 2736–47. doi:10.1161/CIRCULATIONAHA.110.009449. PMID 21670242.
  2. Sabatine MS, Morrow DA, Giugliano RP, Burton PB, Murphy SA, McCabe CH; et al. (2005). "Association of hemoglobin levels with clinical outcomes in acute coronary syndromes". Circulation. 111 (16): 2042–9. doi:10.1161/01.CIR.0000162477.70955.5F. PMID 15824203.

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