Fibroma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2], Simrat Sarai, M.D. [3]


Common complications of chondromyxoid, ossifying and non-ossifying fibroma include pathological fractures. Depending on the type of the fibroma, the prognosis may vary. However, the prognosis is generally regarded as excellent for nonossifying fibroma. Ossifying fibromas tend to regress over time. Ossifying fibroma is noninvasive tumor. It will recur if it is excised before skeletal maturity. Excision after skeletal maturity is usually successful. Oral fibromas are benign tumors. Recurrence of oral fibromas is possible, however, if the offending irritant persists. Desmoplastic fibromas are benign and locally aggressive tumors. Desmoplastic fibroma is a rare benign intraosseous tumor neoplasm. Desmoplastic fibroma has a recurrence rate of approximately 37% to 72%. The average rate of recurrence after curettage has been reported to be approximately 55%.

Natural History

Cemento-ossifying fibroma

  • Clinically, cemento-ossifying fibroma manifest as a slow-growing intrabony mass that is normally well delimited and asymptomatic, although over time the lesion may become large enough to cause facial deformation. Cemento-ossifying fibroma is a benign fibro-osseous maxillary tumor. It is a slow-growing lesion. Approximately one-half of all cases are asymptomatic, the growth of the tumor over time may lead to facial asymmetry, with the appearance of a mass causing facial discomfort or mandibular expansion, and the possible displacement of dental roots. Juvenile aggressive cemento-ossifying fibroma presents in children and is clinically more aggressive and pathologically more vascular.[1]

Chondromyxoid Fibroma

Oral Fibroma

Desmoplastic Fibroma

  • Desmoplastic fibroma (DF) is an extremely rare benign intraosseous tumor with locally aggressive and infiltrative characteristics. The clinical presentation of desmoplastic fibroma is nonspecific and usually presents as pain over the affected area and occasionally as a palpable mass, although pathologic fracture has been described previously as a common reason for seeking treatment. Desmoplastic fibroma has also been presented as an incidental finding. The most common sites of involvement are the mandible and the metaphysis of long bones. Biologically and histologically, desmoplastic fibroma mimics extra-abdominal desmoid tumor of soft tissue. Morphologically a distinction between desmoplastic fibroma and aggressive fibromatosis (desmoid tumor) is not possible.[17][18][19]

Non-ossifying Fibroma


Ovarian Fibroma

Ossifying- Fibroma

Non-ossifying Fibroma

Chondromyxoid fibromas

Uterine Fibromas


Non-ossifying Fibroma

Oral Fibromas

Ovarian Fibromas

Ossifying Fibroma

Pleural Fibroma


Cemento-ossifying Fibroma

  • Recurrence following complete excision of cemento-ossifying fibroma is generally considered to be uncommon. However, in some series, it has been reported to be approximately 16%.

Desmoplastic Fibroma

Sclerotic Fibroma

Uterine Fibroma

Peripheral odontogenic fibroma

Giant cell fibroma


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