Fibroma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2], Simrat Sarai, M.D. [3]


Patients of all age groups may develop fibromas. However, the majority of fibromas are observed in adults. Fibromas usually affects men and women equally, however certain fibromas may show gender predilection. Fibromas are most often observed in adults, but they may occur in individuals of any age and either sex.

Epidemiology and Demographics

Non-ossifying Fibroma


The prevalence of non-ossifying fibroma is estimated to be 30-40 % of all normal children.


Non-ossifying fibromas are the most common fibrous bony lesions in children and adolescents, with a peak incidence at 10-15 years old. Non-ossifying fibromas are not seen beyond the age of 30 years, as they spontaneously heal. The age of presentation of the isolated mandibular non-ossifying fibroma appears to differ from that of the long bones in that the mandibular NOF appears at an older average age at diagnosis. The overall incidence of non-ossifying fibromas in the long bones is 30–40 % of children over the age of 2 with the highest incidence between ages 4 and 8 years.


Males are more commonly affected with non-ossifying fibromas of the long bones than females. The male to female ratio is approximately 2 to 1. Females are more commonly affected with mandibular NOF than males.

Desmoplastic Fibroma


The incidence of desmoplastic fibroma is approximately 0.11% of all primary bone tumors.[1][2]


The median age at presentation is 21 years.


Desmoplastic fibromas affects men and women equally.

Ovarian Fibroma

Ovarian fibromas represent 4% of all ovarian neoplasms. They tend to occur mostly during perimenopause and postmenopause.[3][4][5]


Patients of all age groups may develop ovarian fibroma. However, they are most frequently seen in middle-aged women. The median age at diagnosis is 52 years. Ovarian fibromas commonly affects individuals during perimenopause and postmenopause. They are rare in children.

Ossifying Fibroma


Ossifying fibromas most frequently occur in young children (less than 10 years of age). The median age at diagnosis for females and for males is 13 years and 10 years respectively.[6][7]


Ossifying fibromas affects men and women equally.

Chondromyxoid Fibroma

A chondromyxoid fibroma (CMF) is an extremely rare benign cartilaginous neoplasm which accounts for < 1% bone tumours.[8][9][10]


Chondromyxoid fibromas affects men and women equally.


Patients of all age groups may develop chondromyxoid fibroma. However, they are most frequently seen in second and third decades. Approximately 75% of cases occur before the age of 30 years. The location of chondromyxoid fibroma(CMF) varies with age. It is found predominantly in long bones between 1 and 10 years, while the distribution of localization becomes equal between the long bones, flat bones and ribs in the fourth decade. According to some authors, the average age for intracranial CMF is 37 – 39 years. It is 32.7years (range 15-50 years) among patients who have frontal CMF.The duration of the symptoms before diagnosis varies between 10 days and 20 years.[11]

Cardiac Fibroma


Cardiac fibromas primarily affects children, the majority of cases are detected in infants or in utero. They are the second most common benign primary cardiac tumour in children after cardiac rhabdomyoma and second commonest fetal cardiac tumor.[12]

Pleural Fibromas


Pleural fibromas affects men and women equally.[13][14]


Pleural fibromas usually presents in the 6th to 7th decades.

Cemento-ossifying Fibroma


Cemento-ossifying fibromas are most frequently diagnosed during the third and fourth decades. Occasionally, they are identified in children, in which case they are a more aggressive variant and are known as juvenile aggressive cemento-ossifying fibromas. Patients of all age groups may develop cemento-ossifying fibroma. Cemento-ossifying fibroma commonly affects individuals 10-20 years of age.[15][16][17][18]


Females are more commonly affected with cemento-ossifying fibromas than males. The female to male ratio is approximately 3 to 2.

Oral Fibroma

Oral fibromas are the most common oral cavity tumors.[19]


Patients of all age groups may develop oral fibromas. However, they are most commonly seen in older adults, usually 30-50 years old. It affects 1-2% of adults. It is the most common oral cavity tumour.


Females are more commonly affected with oral fibromas than males. The female to male ratio is approximately 2 to 1.

Giant cell fibroma


Patients of all age groups may develop giant cell fibroma. The majority of cases of giant cell fibroma are diagnosed in persons aged 10-30 years.[20][21][22][23]


Giant cell fibromas affects men and women equally.



Elastofibroma commonly affects individuals older than 50 years of age. Elastofibroma is a rare disease that tends to affect elderly population (< 0.001% of soft tissue tumors).[24][25]


Females are more commonly affected with elastofibroma than males. The female to male ratio is approximately 5 to 1.

Uterine Fibroma


Uterine fibromas occur in approximately 25% of women of reproductive age. Approximately 40% of women by age 40 years develop uterine fibromas. Uterine fibromas commonly affects females after puberty, they commonly accelerate in growth during pregnancy and involute with menopause. Uterine fibromas commonly affects individuals older than 30 years of age. Approximately 20% to 80% of women develop fibroids by the age of 50.[26][27][28][29][30]


In 2013, it was estimated that 171 million women were affected by uterine fibromas worldwide.[31][32][33][34]


Uterine fibromas usually affects individuals of the African race. Caucasian females are less likely to develop uterine fibromas. African American women are two to three times more likely to get fibroids than Caucasian women. In African-American women fibroids seem to occur at a younger age, grow more quickly, and are more likely to cause symptoms.According to the National Institute of Environmental Health Sciences, eighty percent of African American women will develop benign uterine fibroid tumors by their late 40s.[35][36][37]

Peripheral Odontogenic Fibroma

It is a rare lesion


Patients of all age groups may develop peripheral odontogenic fibroma. Peripheral odontogenic fibroma commonly affects individuals ranged from 5 to 65 years of age.[38][39][40]


Peripheral odontogenic fibromas affects men and women equally.


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  2. Vasconcelos AC, Gomes AP, Tarquinio S, Abduch-Rodrigues E, Mesquita R, Silva K (January 2018). "Oral Bilateral Collagenous Fibroma: A previously unreported case and literature review". J Clin Exp Dent. 10 (1): e96–e99. doi:10.4317/jced.54123. PMC 5899808. PMID 29670724.
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