Cirrhosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Sudarshana Datta, MD [3]


Lifestyle and genetic risk factors play an important role in the development of cirrhosis in patients. Chronic alcohol use, chronic hepatitis B and C infection and genetic diseases such as cystic fibrosis are also significant risk factors for the development of cirrhosis.

Risk Factors

The risk factors of cirrhosis are as follows:


  1. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Crocè L, Sasso F, Pozzato G, Cristianini G, Brandi G (1997). "Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group". Gut. 41 (6): 845–50. PMC 1891602. PMID 9462221.
  2. Poynard T, Bedossa P, Opolon P (1997). "Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups". Lancet. 349 (9055): 825–32. PMID 9121257.
  3. Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Crocè LS, Mazzoran L, Masutti F, Cristianini G, Tiribelli C (1999). "Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study". Gut. 44 (6): 874–80. PMC 1727553. PMID 10323892.
  4. Clark JM (2006). "The epidemiology of nonalcoholic fatty liver disease in adults". J. Clin. Gastroenterol. 40 Suppl 1: S5–10. doi:10.1097/01.mcg.0000168638.84840.ff. PMID 16540768.
  5. Farrell GC, Larter CZ (2006). "Nonalcoholic fatty liver disease: from steatosis to cirrhosis". Hepatology. 43 (2 Suppl 1): S99–S112. doi:10.1002/hep.20973. PMID 16447287.

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