Anaphylaxis future or investigational therapies

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Anaphylaxis Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD


Investigational therapy for anaphylaxis include various forms of immunotherapy and monoclonal antibodies. [1]

Future or Investigational Therapies

Investigational therapies include subcutaneous, oral, sublingual, and epicutaneous immunotherapies. Subcutaneous immunotherapy has been used for allergies to pollen and peanuts. Oral immunotherapy has also been used for peanuts, as well as milk and egg. However, it has been found that while these patients are able to develop desensitization to their food allergies, if they don't continue regular intake, then their anaphylactic reactions can resurface. Sublingual immunotherapy has been used for kiwi, hazelnut, milk, and peanuts with the allergen placed under the tongue for an extended period of time with much improvement seen. Epicutaneous immunotherapy was recently under experimentation for milk allergies. [1] [2] [3] [4] [5]


  1. 1.0 1.1 Boden SR, Wesley Burks A (2011). "Anaphylaxis: a history with emphasis on food allergy". Immunol Rev. 242 (1): 247–57. doi:10.1111/j.1600-065X.2011.01028.x. PMC 3122150. PMID 21682750.
  2. Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DY (1992). "Treatment of peanut allergy with rush immunotherapy". J Allergy Clin Immunol. 90 (2): 256–62. doi:10.1016/0091-6749(92)90080-l. PMID 1500630.
  3. Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L; et al. (2008). "Specific oral tolerance induction in children with very severe cow's milk-induced reactions". J Allergy Clin Immunol. 121 (2): 343–7. doi:10.1016/j.jaci.2007.10.029. PMID 18158176. Review in: Evid Based Med. 2009 Apr;14(2):50
  4. Rolinck-Werninghaus C, Staden U, Mehl A, Hamelmann E, Beyer K, Niggemann B (2005). "Specific oral tolerance induction with food in children: transient or persistent effect on food allergy?". Allergy. 60 (10): 1320–2. doi:10.1111/j.1398-9995.2005.00882.x. PMID 16135001.
  5. Skripak JM, Wood RA (2009). "Mammalian milk allergy: avoidance strategies and oral desensitization". Curr Opin Allergy Clin Immunol. 9 (3): 259–64. doi:10.1097/ACI.0b013e32832b2218. PMID 19365261.

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