Anaphylaxis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD


Anaphylaxis may be classified into 2 subtypes/groups: Immunologic-IgE mediated and Immunologic-non-IgE mediated. [1]

The diagnostic criteria must have one of the three of the following: [2]


Anaphylaxis may be classified into two groups: [1]

There are also three pattern classifications:

  • Uniphasic which resolves in an hour
  • Biphasic which includes recurrence even without repeated exposure [3]
  • Protracted which can lasts for days [4]

Anaphylaxis can also be categorized according to the cause: [5]


  1. 1.0 1.1 LoVerde D, Iweala OI, Eginli A, Krishnaswamy G (2018). "Anaphylaxis". Chest. 153 (2): 528–543. doi:10.1016/j.chest.2017.07.033. PMC 6026262. PMID 28800865.
  2. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A; et al. (2006). "Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium". J Allergy Clin Immunol. 117 (2): 391–7. doi:10.1016/j.jaci.2005.12.1303. PMID 16461139.
  3. Lee S, Sadosty AT, Campbell RL (2016). "Update on biphasic anaphylaxis". Curr Opin Allergy Clin Immunol. 16 (4): 346–51. doi:10.1097/ACI.0000000000000279. PMID 27253484.
  4. Zisa G, Riccobono F, Calamari AM, D'Antonio CD, Galimberti M (2009). "A case of protracted hypotension as unique symptom of a biphasic anaphylaxis to amoxicillin". Eur Ann Allergy Clin Immunol. 41 (2): 60–1. PMID 19585862.
  5. Tanno LK, Chalmers RJ, Calderon MA, Aymé S, Demoly P, on behalf the Joint Allergy Academies (2017). "Reaching multidisciplinary consensus on classification of anaphylaxis for the eleventh revision of the World Health Organization's (WHO) International Classification of Diseases (ICD-11)". Orphanet J Rare Dis. 12 (1): 53. doi:10.1186/s13023-017-0607-3. PMC 5356259. PMID 28302183.

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