Allergy causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]


Allergy may be caused by genetic, environmental and infectious factors.


Allergy may be caused by genetic, environmental and infectious factors. Anaphylaxis is a life-threatening cause of Allergy.

Common Causes

Common genetic causes of allergy may include[1][2] :

  • HLA class 2 genes
  • Th2 cytokine genes
  • Degranulation and pro-inflammatory responses

Common environmental causes of allergy may include[3]:

  • Exposure to allergen:
    • Foods( Peanut, soy, eggs, shellfish), Drugs (Antibiotics, NSAIDS, Aspirin, Sulfur containing medications etc), Insects(honeybee, bumblebee, Hornet, fire ant etc), Contrast allergy, Latex, Exercise, vaccinations
  • Environmental pollution
  • Alteration of microbiota
  • Agricultural etiology

Common infectious causes of allergy may include[4][5]:

  • Intestinal parasites

Less Common Causes

Less common causes of allergy include:


  1. Janeway, Charles (2001). Immunobiology; Fifth Edition. New York and London: Garland Science. pp. e–book. ISBN 0-8153-4101-6. Unknown parameter |coauthors= ignored (help).
  2. Galli SJ (2000). "Allergy". Curr. Biol. 10 (3): R93–5. PMID 10679332.
  3. Cooper PJ (2004). "Intestinal worms and human allergy". Parasite Immunol. 26 (11–12): 455–67. doi:10.1111/j.0141-9838.2004.00728.x. PMID 15771681.
  4. Macpherson CN, Gottstein B, Geerts S (2000). "Parasitic food-borne and water-borne zoonoses". Rev. - Off. Int. Epizoot. 19 (1): 240–58. PMID 11189719.
  5. Carvalho EM, Bastos LS, Araújo MI (2006). "Worms and allergy". Parasite Immunol. 28 (10): 525–34. doi:10.1111/j.1365-3024.2006.00894.x. PMID 16965288.