Acute kidney injury primary prevention

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Acute kidney injury Microchapters


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Historical Perspective




Differentiating Acute Kidney Injury from other Diseases

Epidemiology and Demographics

Risk Factors


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Primary Prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]


Effective measures for the primary prevention of acute kidney injury include volume expansion and/or fluid therapy, optimization of blood pressure,tight glycemic control, avoidance of drug- and nephrotoxin-induced AKI, recheck renal function 48-72 hours following the radiological contrast media, and low doses of corticosteroids in septic shock patients.

Primary Prevention


  1. Kellum, John A; Leblanc, Martine; Gibney, R T. Noel; Tumlin, James; Lieberthal, Wilfred; Ronco, Claudio (2006). "Primary prevention of acute renal failure in the critically ill". Current Opinion in Internal Medicine. 5 (1): 74–78. doi:10.1097/01.ccx.0000179934.76152.02. ISSN 1535-5942.
  2. Lameire, N.; Van Biesen, W.; Hoste, E.; Vanholder, R. (2008). "The prevention of acute kidney injury: an in-depth narrative review Part 1: volume resuscitation and avoidance of drug- and nephrotoxin-induced AKI". Clinical Kidney Journal. 1 (6): 392–402. doi:10.1093/ndtplus/sfn162. ISSN 2048-8505.
  3. Harty J (September 2014). "Prevention and management of acute kidney injury". Ulster Med J. 83 (3): 149–57. PMC 4255835. PMID 25484464.
  4. Park KM, Kramers C, Vayssier-Taussat M, Chen A, Bonventre JV (January 2002). "Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction". J. Biol. Chem. 277 (3): 2040–9. doi:10.1074/jbc.M107525200. PMID 11696540.

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