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ATPase, Na+/K+ transporting, alpha 1 polypeptide
PDB rendering based on 1mo7.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Symbols ATP1A1 ; MGC3285; MGC51750
External IDs Template:OMIM5 Template:MGI HomoloGene564
RNA expression pattern
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

ATPase, Na+/K+ transporting, alpha 1 polypeptide, also known as ATP1A1, is a human gene.[1]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]


  1. 1.0 1.1 "Entrez Gene: ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide".

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. 38: 37–89. PMID 2158121.
  • Dunbar LA, Caplan MJ (2001). "Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases". J. Biol. Chem. 276 (32): 29617–20. doi:10.1074/jbc.R100023200. PMID 11404365.
  • Wangemann P (2002). "K+ cycling and the endocochlear potential". Hear. Res. 165 (1–2): 1–9. PMID 12031509.
  • Xie Z, Cai T (2004). "Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function". Mol. Interv. 3 (3): 157–68. doi:10.1124/mi.3.3.157. PMID 14993422.
  • Shull MM, Pugh DG, Lingrel JB (1990). "The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism". Genomics. 6 (3): 451–60. PMID 1970326.
  • Herrera VL, Ruiz-Opazo N (1990). "Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution". Science. 249 (4972): 1023–6. PMID 1975705.
  • Kawakami K, Ohta T, Nojima H, Nagano K (1986). "Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence". J. Biochem. 100 (2): 389–97. PMID 2430951.
  • Yang-Feng TL, Schneider JW, Lindgren V; et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. PMID 2842249.
  • Sverdlov ED, Broude NE, Sverdlov VE; et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. PMID 2887455.
  • Chehab FF, Kan YW, Law ML; et al. (1987). "Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7901–5. PMID 2891135.
  • Ovchinnikov YuA , Monastyrskaya GS, Broude NE; et al. (1987). "The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit". FEBS Lett. 213 (1): 73–80. PMID 3030810.
  • Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. PMID 3035563.
  • Sverdlov ED, Monastyrskaya GS, Broude NE; et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. PMID 3036582.
  • Ruiz A, Bhat SP, Bok D (1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium". Gene. 155 (2): 179–84. PMID 7536695.
  • Hundal HS, Maxwell DL, Ahmed A; et al. (1995). "Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle". Mol. Membr. Biol. 11 (4): 255–62. PMID 7711835.
  • Feschenko MS, Sweadner KJ (1995). "Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C.". J. Biol. Chem. 270 (23): 14072–7. PMID 7775468.
  • Ruiz-Opazo N, Barany F, Hirayama K, Herrera VL (1994). "Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats". Hypertension. 24 (3): 260–70. PMID 8082931.
  • Zahler R, Gilmore-Hebert M, Baldwin JC; et al. (1993). "Expression of alpha isoforms of the Na,K-ATPase in human heart". Biochim. Biophys. Acta. 1149 (2): 189–94. PMID 8391840.
  • Wang J, Schwinger RH, Frank K; et al. (1996). "Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart". J. Clin. Invest. 98 (7): 1650–8. PMID 8833915.

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