Trichlormethiazide

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Trichlormethiazide
Trichlormethiazide.png
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Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • B (D if used to treat pregnancy-induced hypertension)
Routes of
administration
Oral (capsules, tablets, oral solution)
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariably absorbed from GI tract
ExcretionPrimarily excreted unchanged in urine
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC8H8Cl3N3O4S2
Molar mass380.6558 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Trichlormethiazide (currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1]

Pharmacology

As a diuretic (in particular a thiazide), Trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl- ion reabsorption from the distal tubules of the kidneys.[1] In addition, Trichlormethiazide increases the excretion of potassium.[1]

Mechanism

Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although Trichlormethiazide is used to treat hypertension, it's hypotensive effects may aren't necessarily due to their role as a diuretic.[1] Thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "DrugBank: DB01021 (Trichlormethiazide)". DrugBank. Retrieved 2008-01-23.

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